Quest for Efficacious Cancer Chemotherapy based on the Next-Generation Taxanes and Their Tumor-Targeted Delivery
Abstract Paclitaxel (Taxol®) and docetaxel are among the most widely used chemotherapeutic drugs against various types of cancer. However, these drugs cause undesirable side effects as well as drug resistance. Therefore, it is essential to develop next-generation taxane anticancer agents with better pharmacological properties and improved activity especially against drug-resistant and metastatic cancers. Our studies have led to the development of numerous highly potent novel second- and third-generation taxanes. The third-generation taxanes show virtually no difference in potency against drug-resistant and drug-sensitive cell lines. Some of the next-generation taxanes also exhibit excellent potency against cancer stem cells, which are the cause of cancer recurrence and metastasis. This lecture concisely presents investigations into taxanes over 25 years based on a strong quest for the discovery and development of next-generation taxanes and their highly efficacious tumor-targeted drug delivery. The critical importance of multidisciplinary research in these endeavors, as well as emerging academia-industry collaborations in drug discovery will also be discussed. Information Date: Friday, March 15, 2019 Time: 5:45 PM ~ 8:00 PM (5:45 PM doors open, 6:15 PM – 8 PM lecture and Q&A) Location: University of Tokyo New York Office, 145 West 57th St. 21st Fl., NYC Language: The lecture will be in English, the Q&A can be in Japanese Fee: $20 (Beverage and appetizers)
Minami Goto, Film Director and FUTI Scholarship Recipient, Introduces Her Short Film, “Breakers”
(Only in Japanese) 「スニークプレビュー短編映画 ”ブレイカーズ”」 コロンビア大フィルム学部を昨年卒業された後藤美波さん（東大OG）を囲む講演・懇親会を企画致しました。皆様、是非御参加ください。お友達、ご家族の参加も大歓迎です。
Next Generation Cancer Treatment Development: The Role of Protein Design
(In Japanese) 「次世代がん治療法の開発：タンパク質デザインの役割」 タンパク質デザイン分野で国際的に著名な研究者でおられる小出教授には上記のテーマでお話いただきます。 本年のノーベル医学賞と化学賞に直接関連のある非常にタイムリーなテーマであるため、 質疑応答の時間も十分に取ってございます。
The Technology to Gain Knowledge About the Ocean
(In Japanese) タイトル：海を知るためのテクノロジー 東大執行役･副学長でおられる藤井輝夫教授を囲む講演・懇親会を企画致しました。 皆様、是非御参加ください。お友達、ご家族の参加も大歓迎です。教授は東京大学社会連携本部長もなされています。 マイクロフルイディクス分野で国際的に著名な研究者でおられる藤井教授には[海を知るためのテクノロジー]というテーマでお話いただきます。 非常にタイムリーなテーマであるため、皆様からの質問も多いと思われますので、質疑応答の時間も十分に取ってございます。
Recent Developments and Future of Artificial Intelligence (AI)-A Path Recommended for Science and Technology Research in Japan
(In Japanese) タイトル：「AI（人工知能）の最近の進歩と将来～日本の科学技術研究の進むべき道～」 東工大名誉教授・栄誉教授、Toyota Technological Institute at Chicago (TTIC)学長でおられる古井貞熙氏(東大OB)を囲む講演・懇親会を企画致しました。 皆様、是非御参加ください。お友達、ご家族の参加も大歓迎です。教授は東京大学総長諮問機関（Global Advisory Board）のメンバーもなされています。
Issues in the Political Situation and Economic Policy in Japan after the General Election
(In Japanese) タイトル：「総選挙後の政治状況と経済政策の課題」 コロンビア大学教授（兼）政策研究大学院大学（夏季）特別教授でおられる伊藤 隆敏氏を囲む講演・懇親会を企画致しました。 皆様、是非御参加ください。お友達、ご家族の参加も大歓迎です。教授はコロンビア大学School of International Public Affairs (SIPA) でProfessor of International and Public Affairsをしておられます。
Sleep and Sleeping Pills
(In Japanese) タイトル：”睡眠・睡眠薬” 松木則夫政策ビジョン研究センター特任教授が１０月上旬に東大友の会理事会出席のためニューヨークに来られますので、同氏を囲む講演・懇親会を企画致しました。皆様、是非御参加ください。お友達、ご家族の参加も大歓迎です。松木教授は東大の理事・副学長でおられ、また東大友の会の理事もしておられます。
Brown Bag Lunch Featuring Minister Jun Saito: “Social Advancement of Japanese Women: Viewed from a Global Perspective”
Lecture: “Social Advancement of Japanese Women: Viewed from a Global Perspective” Lecturer: Minister Jun Saito, Permanent Mission of Japan to the Unite Nations. With the support of Friends of UTokyo, Satsuki-kai America organized a brown bag lunch discussion featuring Minister Jun Saito of Permanent Mission of Japan to the United Nations. Mr. Saito is in charge of the Human Rights and Humanitarian Affairs at the Mission. He served as co-chair of the 60th and 61st session of the UN Commission on the Status of Women (in 2016 and 2017, respectively). Prior to his assignment in New York, Mr. Saito served at Japanese Embassy in Bruxelles, New Delhi, and Paris.
New York Lecture by Dr. Yoshinori Ohsumi, Recipient of the 2016 Nobel Prize in Physiology and Medicine
On April 21, 2017, Dr. Yoshinori Ohsumi, Professor Emeritus of the Tokyo Institute of Technology, will give a lecture in New York titled “Reflections Since Receiving the Noble Prize”. The event will be organized by Satsuki-kai America and supported by Friends of UTokyo, Inc.
Expression in violin performance: innovations in the late 19th century
By Ray Iwazumi, internationally respected violinist and musicological scholar Friends of UTokyo is pleased to announce a presentation by Dr. Ray Iwazumi, internationally respected violinist and musicological scholar and faculty member at the Juilliard School. The lecture, “Expression in violin performance: innovations in the late 19th century” will be presented for music enthusiasts as well as aspiring young violinists/musicians. The lecture is a reflection of Ray’s multi-faceted career as a violinist, composer, lecturer, writer, editor and teacher, and presents his latest research into violin virtuoso music of the late 19th century. Along with demonstrations, this will be an evening of fun, pleasure and inspiration.